AFRL researchers support flu vaccine development


Submitted photo Lindsey White and Tiffany Miracle prepare serology samples to load into an automated analysis system in the immunodiagnostic section of the Epidemiology Laboratory Service, also known as the ‘Epi Lab,’ at the 711th Human Performance Wing’s United States Air Force School of Aerospace Medicine and Public Health at Wright Patterson Air Force Base.

Submitted photo Lindsey White and Tiffany Miracle prepare serology samples to load into an automated analysis system in the immunodiagnostic section of the Epidemiology Laboratory Service, also known as the ‘Epi Lab,’ at the 711th Human Performance Wing’s United States Air Force School of Aerospace Medicine and Public Health at Wright Patterson Air Force Base.


WRIGHT-PATTERSON AIR FORCE BASE — The United States is currently in the midst of influenza season, but the medical readiness of airmen across the Air Force is being supported by a DOD-wide respiratory pathogen surveillance program located at the United States Air Force School of Aerospace Medicine.

The Centers for Disease Control and Prevention is reporting 19 million cases, 180,000 hospitalizations, and 10,000 deaths in the U.S. alone.

The USAFSAM Epidemiology Lab, part of the Air Force Research Laboratory’s 711th Human Performance Wing, is the sole clinical reference lab for the Air Force. It provides force health screening, as well as clinical diagnostic testing for its customers around the world.

In Episode 21 of AFRL’s “Lab Life” podcast, Dr. Anthony Fries, a bioinformatics scientist and Dr. Paul Sjoberg, a program manager with the Department of Defense Global Respiratory Pathogen Surveillance Program at USAFSAM’s Epi Lab, discuss how the lab and CDC monitor influenza to provide the U.S. Food and Drug Administration with critical data to facilitate the creation of the influenza vaccine each season.

Sjoberg explained how the surveillance program works to identify changes in viruses.

“We’re actually out globally at military installations and collecting specimens from individuals that are ill. We are looking for certain symptoms that would help us potentially identify a respiratory virus and specifically, influenza. Do they have a fever, or a cough and a sore throat?”

Sjoberg continued, “We work with military installations here in the United States and abroad to see if something is occurring and work with the CDC and FDA here in the United States and the World Health Organization globally to provide that change, if necessary.”

Sjoberg explained that as they look at the changes within the virus to determine if there are mutations occurring, they are also looking for anything unique that stands out. However, responding to changes in the virus does take some time.

“Our vaccine manufacturing process takes a long time – six to eight months from when you make decisions about what you think the population should be vaccinated against in the coming flu season,” Fries said.

Fries explained that in February, in the northern hemisphere, the World Health Organization, Centers for Disease Control, Food and Drug Administration, and the Defense Department get together and make decisions on the upcoming season according to what has been seen thus far.

“At that point, you characterize and do your best effort to take a very educated guess from a lot of data that have been accrued to say to the industry reps that are sitting at the table with you, ‘These are the candidate viruses that we think you should take back to your labs. We want you to grow those in mostly egg-based systems and amplify it and grow it enough that we can then mass distribute it across the globe to the benefit of the prevention of influenza.’ ”

Sjoberg shared a success story for the DOD surveillance program at the Epi Lab that relates to the concern with the pandemic influenza virus that emerged in 2009.

“In 2009, there was the H1N1 pandemic. Because of what we were able to do in our lab and in our partner lab in California (the Naval Health Research Center), we identified the first H1N1 viruses in the United States in California and Texas. The CDC asked for that virus, and that virus was then utilized as a seed virus for that pandemic vaccine. Our program provides the ability to quickly identify something that is occurring in the population that is responsive to the needs of not only the U.S., but globally,” Sjoberg said.

To hear more about USAFSAM’s Epi Lab and its work on the flu vaccine, tune in to AFRL’s “Lab Life” podcast.

Submitted photo Lindsey White and Tiffany Miracle prepare serology samples to load into an automated analysis system in the immunodiagnostic section of the Epidemiology Laboratory Service, also known as the ‘Epi Lab,’ at the 711th Human Performance Wing’s United States Air Force School of Aerospace Medicine and Public Health at Wright Patterson Air Force Base.
https://www.xeniagazette.com/wp-content/uploads/sites/32/2020/02/web1_180130-F-LW859-127A.jpgSubmitted photo Lindsey White and Tiffany Miracle prepare serology samples to load into an automated analysis system in the immunodiagnostic section of the Epidemiology Laboratory Service, also known as the ‘Epi Lab,’ at the 711th Human Performance Wing’s United States Air Force School of Aerospace Medicine and Public Health at Wright Patterson Air Force Base.