CEDARVILLE — Collaborative research by Cedarville senior biomedical engineers and the school of pharmacy shows that 3D printing of human tissue scaffolds has tremendous potential for regrowing bone.
Their research will be published by the Orthopedic Research Society (ORS) in March 2018.
3D printing is commonly associated with the industrial design field, where printers are used to create prototypes or actual parts for cars, planes and machinery or scale architectural and other types of models. Now 3D printing is being employed to recreate human organs and bone-building scaffolds.
The biomedical engineering students working on this project are seniors Mitchell Ryan, Daniel Sidle, Stephan Smith, Jacob Cole, Tierra Martinelli, and freshman Sarah Seman.
According to Dr. Tim Norman, professor of mechanical and biomedical engineering, biomedical engineering and pharmacy students are producing a scaffold, which is like a frame for bone tissue cells to grow, using a 3D printer. PLA (polylactic acid) is used in the printer; it is a biocompatible and biodegradable substance. The scaffold is a framework with which the cells will easily inhabit and mimics the body tissue being regrown.
The scaffold is submerged into a liquid growth media full of normal endothelial cells that will attach to the scaffold and reproduce. The biomedical engineering design group is partnering with Dr. Rocco Rotello, associate professor of pharmaceutical sciences, to culture human cells in the pharmaceutical science laboratory.
Ideally, the cell-enriched scaffold would be implanted into the body to eventually regrow the missing tissue. The scaffold is resorbed by the patient’s body, while the cells produce the new tissue.
“The biomedical field is growing and moving so quickly, and this project reveals the interdisciplinary nature of this field extremely well,” Norman said. “It shows our students that collaborative work with other disciplines is necessary for successful biomedical engineering projects.”
Cedarville began this research in 2015 and is still in the early stages of the research process. The biomedical engineering department’s research paper about the material properties of 3D printed scaffolds will be published in March 2018 at the ORS annual meeting in New Orleans.
The end goal of this research is to design a scaffold that supports cell life and represents the tissue it is meant to replace.
Story courtesy Cedarville University.
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